There's a clinical trial from Oxford University. The VITACOG trial. They gave people with early memory concerns active B vitamins for two years. Then they scanned their brains.
In the memory-critical regions, the people taking active B vitamins lost brain tissue seven times slower than the people taking nothing. Not a small margin. Seven times.
I thought about losing my train of thought with my daughter. About reaching for a word and finding nothing there. And about all the patients I'd sent home with the same advice.
Sleep. Stress. Diet.
I had been thinking about B vitamins as one thing. One name on a bottle. I hadn't been looking at the form underneath it.
The distinction was between inactive forms, which the body converts first, and active forms used in its biochemical processes.
First B12. Cyanocobalamin is a form the body has to convert into the active form called methylcobalamin. B12 supports the nervous system and helps maintain myelin, the protective coating around nerve fibres.
Then B9, or folate. Folic acid is a form the body converts into active folate which is 5-MTHF. This regulates the levels of homocysteine, a toxic compound linked to dementia.
Then B6. Pyridoxine is a form the body converts into P5P, the active form used by enzymes, including those involved in making serotonin and dopamine. the chemicals responsible for mood and clarity.
Three vitamins I'd heard of for years. Three ingredient names I now knew to look for.
Methylcobalamin. 5-MTHF. P5P.
I ordered a B complex from a health food shop.
Figured I had nothing to lose.
After two weeks, I noticed a very slight improvement. Maybe a little more alert in the mornings. But nothing significant. The fog was still there.